Formulasi dan evaluasi gel Lidah buaya (Aloe vera Linn) sebagai pelembab kulit dengan penggunaan carbopol sebagai gelling agent

Authors

  • Benni Iskandar Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
  • Zyzy Permata Dian Rumah Sakit Syafira, Pekanbaru
  • Fitri Renovita Rumah Sakit Syafira, Pekanbaru
  • Leny Leny Institut Kesehatan Helvetia, Medan

DOI:

https://doi.org/10.32504/hspj.v5i1.381

Keywords:

Carbopol, gel, Aloe vera

Abstract

Indonesia is a rich country in natural resources. Aloe vera (Aloe vera Linn) is a natural resource that has the potential to be developed. Aloe vera (Aloe vera Linn) has been shown to have a function as a skin moisturizer. The purpose of this study was to determine whether the aloe vera gel formulation has fulfilled the evaluation requirements in accordance with existing standards. This research was conducted by making aloe vera gel preparations in two formulas with carbopol variance, namely each with a concentration of 0,5% (F1), 1% (F2). Evaluation of gel preparations includes organoleptic, pH measurement, stability check at room temperature and cold temperature, spread-ability test, adhesion test, homogeneity test, and irritation test. The study was conducted for 2 months for stability, every week for pH measurement and at week 1 and week 8 on the dispersion and gel-ability, while the homogeneity and irritation tests were carried out after completing the formulation. The results showed that the evaluations that have fulfilled the requirements were organoleptic evaluation, stability at room temperature and cold temperature, homogeneity, and irritation. The evaluations that did not meet the requirements were the pH measurements at F1 and the spread-ability in both formulas.

Author Biography

Benni Iskandar, Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru

Department of Pharmaceutical Technology

References

BPOM. RI 2014, Peraturan Kepala Badan Pengawas Obat dan Makanan RI No. HM.03.03.1.43.12.14.7870 tentang Kosmetika yang Mengandung Bahan Berbahaya, Biro Hukum dan Hubungan Masyarakat Badan Pengawas Obat dan Makanan. Jakarta : 6-222

Mohiudin, AK. (2019). Skin care: Formulation and use. American journal of dermatological research and reviews. 2 (8).

Tranggono, R. I. dan Latifah, F. 2018. Buku Pegangan Ilmu Pengetahuan Kosmetik edisi kedua. Jakarta: Gramedia Pustaka Utama

Salawu, K. M., Ajaiyeoba, E. O., Oluyemisi, O., Adeniji, J. A., & Faleye, T. C. 2017. Antioxidant, Brine Shrimp Lethality, and Antiproliferative Properties of Gel and Leaf Extracts of Aloe schweinfurthii and Aloe vera Antioxidant, Brine Shrimp Lethality, and Antiproliferative and Aloe vera. Journal of Herbs, Spices & Medicinal Plants, 00(00), 1–9.

Ganitafuri, H. 2010. Daya Hambat Ekstrak Daun Lidah Buaya (Aloe vera L.) Terhadap pertumbuhan Isolat Klinis Bakteri Streptococcus β hemolyticus In Vitro. Skripsi. Surakarta: Fakultas Kedokteran Universitas Sebelas Maret.

Hadi, Saputro R, Unggul P Juswono dan Chomsin S Widodo. 2013. Pengaruh bengkuang (Pachyrhizus eresus L. urban) Dan Lidah Buaya (Aloe vera) Terhadap Kandungan Radikal Bebas Pada Daging Ayam Yang Diradiasi Dengan Sinar Ultra Violet. Skripsi. Universitas Brawijaya Malang.

Arikumalasari, J; Dewantara, I G.N.A dan Wijayanti, N.P.AD. 2013. Optimasi HPMC Sebagai Gelling Agent Dalam Formula Gel Ekstrak Kulit Buah Manggis (Garcinia mangostana L.). Naskah Publikasi: 145-148.

Anastasya., Rahmat, D., Budiati, A. 2020. Formulasi dan aktivitas gel yang mengandung nanopartikel ekstrak temulawak sebagai antiacne. Jurnal ilmu kefarmasian Indonesia. Vol: 18 (1):118-122.

Iskandar, B. Sidabutar, S.E., Leny. 2021. Formulasi dan evaluasi lotion ekstrak alpukat (persea americana) Sebagai pelembab kulit. Journal of Islamic Pharmacy. 6 (2): 36-45.

Leny, Karsono, Harahap U., 2016, Comparison of Vitamin C (Magnesium Ascorbyl Phosphate) Formulation in Nanoemulsion Spray and Cream as Anti-aging, International Journal of Pharm Tech Research, 9(9); 399-407.

Iskandar, B., Sidabutar Santa Eni, Br., Leny. 2021. Formulasi dan Evaluasi Lotion Ekstrak Alpukat (Persea Americana) sebagai pelembab kulit. Journal of Islamic Pharmacy. Vol. 6 (1) : 16-21.

Iskandar, B., Karsono., Silalahi, J. 2016. Preparation of Spray Nanoemulsion and Cream Containing Vitamin E as Anti-aging Product Tested in Vitro and in Vivo Method. International Journal Pharma Tech Research. 9(6): 307-308.

Mappa, T., H.J., E. and K.N., 2013. Formulasi Gel Ekstrak Daun Sasaladahan (Peperomia pellucid L.) dan Uji Efektivitasnya Terhadap Luka Bakar pada Kelinci (Oryctolagus cuniculus), Jurnal Ilmiah Farmasi, 2(2), pp.49–56.

Rowe, R.C, Sheskey, P.J, and Quinn, M.E. 2009. Handbook of Pharmaceutical Excipients6th Edition. London: The Pharmaceutical Press.

Leny et al., 2020, Formulation and Evaluation of Candlenut (Aleurites moluccana L.) Oil in Gel Preparation, Asian Journal of Pharmaceutical Research and Development, 8(5):41-43.

Iskandar, B., Putri, DD., Firmansyah, F., Frimayanti, N., Agustini, TT. (2019). Evaluasi sifat fisik dan uji kelembaban sediaan losion yang dijual secara online shop. Jurnal dunia farmasi, 4 (1), 8-16.

Joseph, B ,& Raj, S.J. 2010. Pharmacognostic and phytochemical properties of Aloe vera linn an overview. International journal of pharmaceutical sciences review and research..

Zulkarnain, A.K. dan Oktaviasari L., 2021, Formulation and Physical Stability Test of Lotion O/W Potato Starch (Solanum tuberosum L.) and the Activities as Sunscreen, Majalah Farmasetik, 13(1):9-27.

Downloads

Published

2021-11-27

Issue

Vol. 5 No. 1 (2021)

Section

Articles

Citation Check

License

Formal legal provisions for accessing digital articles in electronic journals must be based on the Creative Commons Attribution-ShareAlike (CC BY-SA) license terms, which means the Health Sciences and Pharmacy Journal reserves to save, to transfer media / format, to manage in the form of databases, to maintain, and to publish articles without asking permission from the author as long as they include the author's name as the copyright owner.